Rifaximin is a non-aminoglycoside semi-synthetic antibacterial derived from rifamycin SV. It inhibits bacterial RNA synthesis by binding to the bacterial DNA-dependent RNA polymerase and has antibacterial activity against Escherichia coli (E. coli).
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Hepatic encephalopathy: To reduce risk of overt hepatic encephalopathy recurrence: 550 mg twice daily
Traveller’s diarrhoea caused by non-invasive strains of E. coli: 200 mg tid for 3 days
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