Salmeterol stimulates intracellular adenyl cyclase, the enzyme that catalyses the conversion of ATP to cyclic-3′,5′-adenosine monophosphate (cAMP) resulting in relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from mast cells.
Salmate (MDI) Inhaler
(in Inhaler form)
Adult: As metered dose aerosol or dry powder inhaler: 50 mcg bid, or up to 100 mcg bid if necessary, in asthma patients w/ more severe airways obstruction.
Child: 4-12 yr 50 mcg bid.
Prophylaxis of exercise-induced asthma:
Adult: As metered dose aerosol or dry powd inhaler: 50 mcg at least 30 min prior to exercise.
Child: ?4 yr Same as adult dose.
Chronic obstructive pulmonary disease:
Adult: As metered dose aerosol or dry powder inhaler: 50 mcg bid.
Manufacturer: Square Pharmaceutical Ltd.