Terbinafine causes fungal cell death by inhibiting squalene epoxidase, the main enzyme in sterol biosynthesis, resulting in ergosterol deficiency within fungal cell walls. It has fungicidal activity against dermatophytes and some yeast.
Adult: 250 mg once daily for 2-4 wk in tinea cruris, 6 wk for tinea pedis, 4 wk for tinea corporis and 6-12 wk for nail infections.
Child: 10-20 kg: 62.5 mg; 20-40 kg: 125 mg; >40 kg: 250 mg. Doses to be taken once daily. Treatment is usually given for 2 wk for tinea capitis; 2-4 wk for tinea cruris; 4 wk for tinea corporis; 6 wk in tinea pedis; 6-12 wk for nail infections.
Adult: Apply a 1% cream/solution once or bid. 1-2 wk to treat tinea corporis and tinea cruris; 1-wk course is for tinea pedis; 2-wk course in cutaneous candidiasis and pityriasis versicolor