Tetracycline exhibits its bacteriostatic action by reversibly binding to the 30S subunits of the ribosome, thus preventing protein synthesis and arresting cell growth. It has a broad spectrum of antimicrobial activity including Chlamydiaceae, Mycoplasma spp., Rickettsia spp., spirochaetes, many aerobic and anaerobic gm+ve and gm-ve pathogenic bacteria, and some protozoa.
Tetracycline Hydrochloride (Oral preparation)
(in Capsule form)
Susceptible infections: 250-500 mg 6 hrly. Max: 4 g/day.
Acne: 250-500 mg daily, in single or divided doses, for at least 3 mth.
Syphilis: 500 mg 4 times daily for 15 days.
Brucellosis: 500 mg 4 times daily for 3 wk in combination with streptomycin.
Gonorrhoea: 500 mg 4 times daily for 7 days.
Susceptible infections: ?12 yr Max: 2 g daily.
Manufacturer: Square Pharmaceutical Ltd.