Fluticasone utilises a fluorocarbothioate ester linkage at the 17 carbon position. It has potent vasoconstrictive and anti-inflammatory activity, but weak hypothalamic-pituitary-adrenal (HPA) inhibitory effect when applied topically.
(in Cream form)
Adult: As 0.05% cream or 0.005% oint: Apply thinly and rub gently to affected area bid for up to 4 wk until improvement occurs.
Child: ?3 mth Apply thinly to affected area bid, withdraw treatment and reassess diagnosis if no improvement is seen w/in 7-14 days.
Adult: As fluticasone propionate drops: 200 mcg into each nostril 1-2 times daily for at least 4-6 wk.
Child: ?16 yr Same as adult dose.
Adult: As fluticasone propionate spray: 100 mcg into each nostril once daily, increased to bid as necessary. As fluticasone furoate spray: 55 mcg into each nostril once daily, may reduce to 27.5 mcg into each nostril once daily if symptoms are controlled.
Child: 4-11 yr As fluticasone propionate spray: 50 mcg into each nostril once daily, increased to bid if necessary. 2-11 yr As fluticasone furoate spray: 27.5 mcg into each nostril once daily, may be increased to 55 mcg into each nostril once daily if necessary.
Adult: As fluticasone propionate powd or aerosol inhaler: 100 mcg bid in mild asthma, up to 500-1,000 mcg bid in severe cases. As nebuliser soln: Severe chronic asthma: 500-2,000 mcg bid. As fluticasone furoate dry powd inhaler: 100-200 mcg once daily.
Child: 4-16 yr As fluticasone propionate powd or aerosol inhaler: 50-100 mcg bid, increased to 200 mcg bid if necessary. As nebuliser soln: 1,000 mcg bid.
Manufacturer: Square Pharmaceutical Ltd.