Tobasol® Respirator Solution is an aqueous solution of Tobramycin. Tobramycin is an aminoglycoside antibiotic and acts primarily by disrupting protein synthesis, leading to altered cell membrane permeability, and eventual cell death. Tobramycin is bactericidal and is active against wide range of Gram-negative organisms including Pseudomonas aeruginosa.
Tobasol Solution for Inhalation
The recommended dosage for, both adult and paediatric patients, 6 years of age and older, is one single-use ampoule (300 mg) administered b.i.d for 28 days. Dosage is not adjusted by weight.
The doses should be taken as close to 12 hours apart as possible; they should not be taken less than 6 hours apart.
If you are taking several medications, the recommended order is as follows: bronchodilator first, followed by chest physiotherapy, then other inhaled medications and finally Tobramycin.
You should take Tobramycin in repeated cycles of 28 days on drug, followed by 28 days off drug. You should take Tobramycin twice a day during the 28 day period on drug.