The usual recommended adult oral dose is 40 mg given once daily, preferably in the morning with or without food. The duration of therapy is ranging from 2-8 weeks.
Duodenal ulcers: Pantoprazole 40 mg tablet once daily for 2-4 weeks.
Gastric ulcer: Pantoprazole 40 mg tablet once daily for 4-8 weeks.
Reflux esophagitis: Pantoprazole 40 mg tablet once daily for 4-8 weeks.
Ulcers induced by NSAIDs: Pantoprazole 40 mg tablet once daily.
Maintenance therapy: Maintenance therapy should involve the lowest effective dose of the drug. Pantoprazole both 20 mg & 40 mg doses are safe and effective in maintaining patients with healed reflux esophagitis and PUD in remission.
Pantoprazole 40 IV Injection-
Treatment of Gastroesophageal Reflux Disease associated with a history of erosive esophagitis: The recommended adult dose is 40 mg Pantoprazole given once daily by intravenous infusion for 7 to 10 days. Pathological
Hypersecretion Associated with Zollinger-Ellison Syndrome: The recommended adult dosage is 80 mg q12h. The frequency of dosing can be adjusted to individual patient needs based on acid output measurements.
Pantoprazole is chemically a novel substituted benzimidazole derivative, which suppresses the final step in gastric acid production by forming a covalent bond to two sites of H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell. This leads to inhibition of both basal and stimulated gastric effect that persists longer than 24 hours.
Pantoprazole is quantitatively absorbed and its bioavailability does not change upon multiple dosing. Pantoprazole is extensively metabolized in the liver. Almost 80% of an oral dose is excreted as metabolites in urine; the remainder is found in feces.