Clozapine is a dibenzodiazepine derivative and an atypical antipsychotics prototype. Its therapeutic efficacy is proposed to be mediated through antagonism of the D2 and 5-HT2A receptors. It also acts as an antagonist at α-adrenergic, histamine H1, cholinergic and other dopaminergic and serotonergic receptors.
Zapenia 100 Tablet
Adult: 12.5 mg 1-2 times on day 1 followed by 25 mg 1-2 times on day 2, increased gradually in increments of 25-50 mg up to a daily dose of 300 mg within 14-21 days. Subsequent increments of 50-100 mg may be made 1-2 times wkly. Usual dose: 200-450 mg daily. Max: 900 mg daily.
Elderly: ≥60 yr Initially, 12.5 mg on day 1 increased subsequently in increments of 25 mg daily.
Psychoses in Parkinson’s disease:
Adult: Initially, 12.5 mg at bedtime, increased in increments of 12.5 mg up to twice wkly, not >50 mg daily at the end of the 2nd wk. Usual dose: 25-37.5 mg daily. Max: 100 mg daily.